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Quality by Design-based Optimization of Formulation and Process Variables for Controlling Particle Size and Zeta Potential of Spray Dried Incinerated Copper Nanosuspension

Author(s):

Saurabh Singh, Sachin Kumar Singh*, Malti G Chauhan, Bimlesh Kumar, Narendra Kumar Pandey, Barinder Kaur, Arun Kumar, Souvik Mohanta, Monica Gulati, Sheetu Wadhwa, Ankit Kumar Yadav, Pankaj Kumar Singh, Yogita Kumari, Gurmandeep Kaur, Rubiya Khursheed and A. Clarrisse   Pages 1 - 13 ( 13 )

Abstract:


Background: In the present study copper nanosuspension was prepared from incinerated copper powder (ICP) by top down media milling. Glycyrrhiza glabra (GG) and gum acacia (GA) were used as stabilizers in the formulation.

Methods: Box Behnken Design was used to investigate the effect of formulation and process variables on particle size and zeta potential and optimize their ratio to get target product profile. The ratio of GA and GG to ICP was varied along with milling time and its speed. Further the prepared nanosuspensions were solidified using spray drying.

Results: The particle size was found to be decreased with increase in GG to ICP ratio, milling time and milling speed, whereas, reverse effect on particle size was observed with increase in GA to ICP ratio. The zeta potential was found to be increased with increase in GG to CB ratio and milling speed and it decreased with increase in GA to ICP ratio and milling time. The obtained value for particle size was 117.9 nm and zeta potential were -9.46 mV which was in close agreement to the predicted values by the design which was, 121.86 nm for particle size and -8.07 mV for zeta potential respectively. This indicated the reliability of optimization procedure. The percentage drug loading of copper in the nanosuspension was 88.26%. The micromeritic evaluation of obtained spray dried nanoparticles revealed that the particles were having good flow and compactibility.

Conclusion: It can be concluded that application of media milling, design of experiment and spray drying have offered very good copper nanosuspension that has potential to be scaled up on industrial scale.

Keywords:

Incinerated copper powder (ICP), Nanosuspension (NS), Media milling, Zeta potential, Particle size, Spray drying (SD)

Affiliation:

School of Ayurvedic Pharmaceutical Sciences, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, Ayurvedic Pharmacopoeia Committee, Pharmacopoeia Commission for Indian Medicine & Homoeopathy, Ghaziabad, Government of India, Uttar Pradesh, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, School of Ayurvedic Pharmaceutical Sciences, Lovely Professional University, Phagwara – 144411, Punjab, School of Ayurvedic Pharmaceutical Sciences, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab, School of Pharmaceutical Sciences, Department of Ayurvedic Pharmacy, Lovely Professional University, Phagwara – 144411, Punjab



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