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Green Procedure for One-Pot Synthesis of Azelaic Acid Derivatives Using Metal Catalysis

Author(s):

Amelita Grazia Laurenza, Michele Casiello, Marco Anzivino, Daniela Caputo, Lucia Catucci, Maria Michela Dell’Anna, Caterina Fusco, Vito Rizzi, Vincenzo Pantone, Lucia D’Accolti* and Angelo Nacci   Pages 1 - 7 ( 7 )

Abstract:


Background & Objective: A green one-pot synthesis of oleic acid (1) derivatives is promoted by Rare Earth Metal (REM) triflates and commercial Molybdenum dioxo dichloride (MoCl2O2) in the presence hydrogen peroxide as a green oxidant. The protocol permits to govern the oxidation selectivity by simply choosing the proper combination of Mo and Sc catalysts. Conclusion: Methyl oleate epoxide 2a and azelaic acid 6 thus obtained are valuable industrial intermediates for synthesizing bio-compostable plastics, plasticizers of PVC, lubricating oils, cosmetics and pharmaceuticals (bactericides, anti-inflammatories, etc.).

Keywords:

removable resource, rare earth, molybdenum complex, sustainability, azelaic acid, green chemistry

Affiliation:

Chemistry Department, University of Bari “Aldo Moro” via Orabona 4, Bari, Chemistry Department, University of Bari “Aldo Moro” via Orabona 4, Bari, Chemistry Department, University of Bari “Aldo Moro” via Orabona 4, Bari, Chemistry Department, University of Bari “Aldo Moro” via Orabona 4, Bari, Chemistry Department, University of Bari “Aldo Moro” via Orabona 4, Bari, Dipartimento di Ingegneria Civile, Ambientale, del Territorio, Edile e di Chimica, Politecnico di Bari, Via Amendola 126/b - 70126 Bari, ICCOM-CNR, SS Bari, Via Orabona 4, 70126 Bari, Chemistry Department, University of Bari “Aldo Moro” via Orabona 4, Bari, Chemistry Department, University of Bari “Aldo Moro” via Orabona 4, Bari, Chemistry Department, University of Bari “Aldo Moro” via Orabona 4, Bari, Chemistry Department, University of Bari “Aldo Moro” via Orabona 4, Bari



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